Article

Stimulator of interferon genes is required for Toll-Like Receptor-8 induced interferon response

2023-05-16

Abstract excerpt

The innate immune system is equipped with multiple receptors to detect microbial nucleic acids and induce type I interferon (IFN) to restrict viral replication. When dysregulated these receptor pathways induce inflammation in response to host nucleic acids and promote development and persistence of autoimmune diseases like Systemic Lupus Erythematosus (SLE). IFN production is regulated by the Interferon Regulatory...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6a8c5976-6312-5df5-9c7e-bc30edcd909b
DOI: 10.1101/2023.05.15.540812

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Stimulator of interferon genes is required for Toll-Like Receptor-8 induced interferon responseDOI 10.1101/2023.05.15.540812Read

Molecular and spatial mechanisms governing STING signallingSemantic proximity Read

Transcription-independent regulation of STING activation and innate immune responses by IRF8 in monocytesSemantic proximity Read

Interferons in Autoimmune and Inflammatory Diseases: Regulation and RolesSemantic proximity Read

Abnormalities of the type I interferon signaling pathway in lupus autoimmunity.Semantic proximity Read

The STING in the Tail for Cytosolic DNA–Dependent Activation of IRF3Semantic proximity Read

IUPHAR ECR review: The cGAS-STING pathway: Novel functions beyond innate immune and emerging therapeutic opportunitiesSemantic proximity Read

The Type I InterferonopathiesSemantic proximity Read

Type I IFN signature in childhood-onset systemic lupus erythematosus: a conspiracy of DNA- and RNA-sensing receptors?Semantic proximity Read

[Review] The Landscape of Interferons in Health and DiseaseSemantic proximity Read

Type I Interferons in the Pathogenesis and Treatment of Autoimmune Diseases.Semantic proximity Read

Interferon regulatory factors: critical mediators of human lupus.Semantic proximity Read

STING is a key driver of Japanese encephalitis virus induced inflammatory responseSemantic proximity Read