Article
The macrophage IRF8/IRF1 regulome is required for protection against infections and is associated with chronic inflammation.
The Journal of experimental medicine - 4 Apr 2016
Langlais David, Barreiro Luis B, Gros Philippe
Abstract excerpt
IRF8 and IRF1 are transcriptional regulators that play critical roles in the development and function of myeloid cells, including activation of macrophages by proinflammatory signals such as interferon-γ (IFN-γ). Loss of IRF8 or IRF1 function causes severe susceptibility to infections in mice and in humans. We used chromatin immunoprecipitation sequencing and RNA sequencing in wild type and inIRF8andIRF1mutant...
Topics
- Animals
- Chronic Disease
- Female
- Genetic Diseases, Inborn
- Humans
- Immunologic Deficiency Syndromes
- Inflammation
- Interferon Regulatory Factor-1
- Interferon Regulatory Factors
- Macrophages
- Male