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The quorum sensing <i>com</i> system regulates pneumococcal colonisation and invasive disease in a pseudo-stratified airway tissue model

2021-12-17

Abstract excerpt

Streptococcus pneumoniae (Spn) colonises respiratory epithelia but can also invade lung cells causing pneumonia. We developed an ex vivo model with human airway epithelial (HAE) cells harvested from lung biopsies to study Spn colonisation and translocation. Flow-cytometry, confocal imaging and electron microscopy studies identified the epithelial lineage with signs of differentiation (beating cilia, mucus, and tig...

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Literature Corpus work
f49b34a2-b459-598e-b320-f5d17c66a14c
DOI
10.1101/2021.12.16.21267943
Open publication

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The quorum sensing <i>com</i> system regulates pneumococcal colonisation and invasive disease in a pseudo-stratified airway tissue modelDOI 10.1101/2021.12.16.21267943
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