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Airway Epithelial Cell Integrity Protects from Cytotoxicity of <i>Pseudomonas aeruginosa</i> Quorum-Sensing Signals

6 Jan 2015

Abstract excerpt

Cell-to-cell communication via gap junctions regulates airway epithelial cell homeostasis and maintains the epithelium host defense. Quorum-sensing molecules produced by Pseudomonas aeruginosa coordinate the expression of virulence factors by this respiratory pathogen. These bacterial signals may also incidentally modulate mammalian airway epithelial cell responses to the pathogen, a process called interkingdom...

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PMID: 25562674
DOI: 10.1165/rcmb.2014-0405oc

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