Article

Disease-attenuated pneumococcal biosynthesis gene mutants invade the mucosal epithelium and induce innate immunity

2023-06-15

Abstract excerpt

<h4>ABSTRACT</h4> Nasopharyngeal colonisation by Streptococcus pneumoniae is characterised by bacterial adherence to epithelial cells, microinvasion and innate immune activation. Previously, we have shown two serotype 6B S. pneumoniae mutant strains affecting bacterial metabolism ( ΔproABC/pia and Δfhs/pia ) colonise humans and mice, but in a murine disease model do not cause invasive infection. Here, we expl...

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Literature Corpus work: d404364b-8cbd-5ff0-95ad-48eacd422cb9
DOI: 10.1101/2023.06.15.545009

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