Article

Epithelial innate immune sensing of pneumococci is inherently restricted to a small cellular minority across species and infection niches

2026-06-10

Abstract excerpt

Streptococcus pneumoniae colonises the nasopharynx asymptomatically yet causes life-threatening invasive disease. How it navigates early epithelial immune surveillance to cause disease remains unclear. Conventional innate immune models predict coordinated, population-wide epithelial responses to bacterial infection. Using single-cell RNA sequencing, RNA fluorescence in situ hybridization and in vivo mouse and zebr...

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Literature Corpus work: 884a0b72-3905-5111-9a4d-ebfb18fe746f
DOI: 10.64898/2026.06.10.731054

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