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A soluble host signal drives rapid, brain-predominant capsular thickening in <i>Streptococcus pneumoniae</i> via a putative sodium-dependent transporter (SPD_0642) and capsular prepromoter sequence

2026-03-30

Abstract excerpt

The Streptococcus pneumoniae capsule is a major determinant of virulence, yet whether bacteria actively remodel it during infection remains unclear. Studying Swiss and South African clinical isolates (serotypes 1, 6B, 8, 12F, 19F, and 35B), we identified a rapid, tissue-specific response: capsule thickness increased within hours upon co-exposure to host cells and tissues. Only two 12F strains failed to thicken. Th...

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Literature Corpus work
d69f9ddd-d591-5e0d-9f52-80c5e27e29da
DOI
10.64898/2026.03.28.714961
Open publication

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A soluble host signal drives rapid, brain-predominant capsular thickening in <i>Streptococcus pneumoniae</i> via a putative sodium-dependent transporter (SPD_0642) and capsular prepromoter sequenceDOI 10.64898/2026.03.28.714961
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