Article

Attenuated interferon signalling in alveolar epithelium limits resistance to <i>Streptococcus pyogenes</i>

2026-04-15

Abstract excerpt

<h4>ABSTRACT</h4> The upper respiratory tract is a primary niche for Streptococcus pyogenes colonisation and disease. Lower respiratory tract infection (pneumonia) is the most common invasive S. pyogenes syndrome. Studies have not previously examined how epithelial cells, from the airway to the alveolus, respond to S. pyogenes infection. Here, we established a scalable human in vitro model by differentiating...

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Literature Corpus work: ab16f856-61ff-5e9a-bd53-5079b9765858
DOI: 10.64898/2026.04.15.718576

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