Article

Structural basis of human LRRK2 membrane recruitment and activation

2022-04-26

Abstract excerpt

<h4>Summary</h4> Mutations in LRRK2 are the most common genetic cause of late-onset Parkinson’s disease (PD). LRRK2 encodes the leucine-rich repeat kinase 2 (LRRK2), whose kinase activity is regulated by Rab29, a membrane-anchored GTPase. However, molecular mechanisms underlying Rab29-dependent recruitment and activation of LRRK2 remain unclear. Here we report cryo-EM structures of LRRK2–Rab29 complexes in thre...

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Literature Corpus work: f49920fd-c78d-55fb-a0bb-5a0be2a92d34
DOI: 10.1101/2022.04.26.489605

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