Article

Parkinson’s Disease-linked LRRK2 structure and model for microtubule interaction

2020-01-06

Abstract excerpt

L eucine R ich R epeat K inase 2 ( LRRK2 ) is the most commonly mutated gene in familial Parkinson’s disease. LRRK2 is proposed to function in membrane trafficking and co-localizes with microtubules. We report the 3.5Å structure of the catalytic half of LRRK2, and an atomic model of microtubule-associated LRRK2 built using a reported 14Å cryo-electron tomography in situ structure. We propose that the conform...

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Literature Corpus work: 59f9c7f2-a9c7-503c-aaac-f6a50365bdce
DOI: 10.1101/2020.01.06.895367

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