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Article

LRRK2 Structure-Based Activation Mechanism and Pathogenesis.

Biomolecules - 28 Mar 2023

Zhang Xiaojuan, Kortholt Arjan

Abstract excerpt

Mutations in the multidomain protein Leucine-rich-repeat kinase 2 (LRRK2) have been identified as a genetic risk factor for both sporadic and familial Parkinson's disease (PD). LRRK2 has two enzymatic domains: a RocCOR tandem with GTPase activity and a kinase domain. In addition, LRRK2 has three N-terminal domains: ARM (Armadillo repeat), ANK (Ankyrin repeat), and LRR (Leucine-rich-repeat), and a C-terminal WD40...

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Identifiers

PMID: 37189360
DOI: 10.3390/biom13040612
PMCID: PMC10135577

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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