Article

Conformation and dynamics of the kinase domain drive subcellular location and activation of LRRK2

2020-07-14

Abstract excerpt

In a multi-tiered approach, we explored how Parkinson’s Disease-related mutations hijack the finely tuned activation process of Leucine-Rich Repeat Kinase 2 (LRRK2) using a construct containing the ROC, Cor, Kinase and WD40 domains (LRRK2 RCKW ). We hypothesized that the N-terminal domains shield the catalytic domains in an inactive state. PD mutations, type-I LRRK2 inhibitors, or physiological Rab GTPases can un...

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Literature Corpus work: ce333545-d132-5237-85cf-2c133e2b4140
DOI: 10.1101/2020.07.13.198069

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