Article

Conformation and Dynamics of the Kinase Domain Drive Subcellular Location and Activation of LRRK2.

2020-08-24

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Leucine-Rich Repeat Kinase 2 (LRRK2) is a complex multi-domain protein where LRRK2-mutations are associated with Parkinson´s Disease (PD). To explore how pathogenic PD-mutations hijack the finely tuned activation process of LRRK2, we here used a multi-tiered approach. <bold>Methods: </bold>First, the spatial and temporal distribution of full-length LRRK2 was inv...

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Literature Corpus work: 017507e2-ce94-5b9f-add3-f3b7bf7ef8ca
DOI: 10.21203/rs.3.rs-59611/v1

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