Article

Structural and biochemical basis of ROC-dependent activation of LRRK2

2026-02-02

Abstract excerpt

<title>Abstract</title> <p>Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial Parkinson’s disease, yet the molecular mechanism governing LRRK2 activation remains incompletely understood. LRRK2 is a large multidomain enzyme whose kinase activity is regulated by intramolecular interactions and by its Ras of complex proteins (ROC) GTPase domain. Here, we combine cryo–electron mic...

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Literature Corpus work: db4d4a72-2ba3-5909-8d83-142e56b66506
DOI: 10.21203/rs.3.rs-8735353/v1

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