Article

Elucidating the molecular interplay between LRRK2 and Rab GTPases

2026-05-05

Abstract excerpt

<h4>ABSTRACT</h4> Gain-of-function mutations in LRRK2 are a major cause of inherited Parkinson’s disease. LRRK2 encodes a multidomain kinase, whose bidirectional interplay with Rab GTPases regulates critical cellular processes like lysosomal homeostasis. Certain Rabs, including Rab12 and Rab29, recruit LRRK2 to organelle membranes and stimulate its kinase activity; activated LRRK2 phosphorylates a subset of Rab...

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Literature Corpus work: e8397331-cdfc-5dde-893f-2667ead79d29
DOI: 10.64898/2026.04.30.722110

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