Article

A Feed-forward Pathway Drives LRRK2 kinase Membrane Recruitment and Activation

2022-04-25

Abstract excerpt

Activating mutations in the Leucine Rich Repeat Kinase 2 (LRRK2) cause Parkinson’s disease and previously we showed that activated LRRK2 phosphorylates a subset of Rab GTPases (Steger et al., 2017). Moreover, Golgi-associated Rab29 can recruit LRRK2 to the surface of the Golgi and activate it there for both auto- and Rab substrate phosphorylation. Here we define the precise Rab29 binding region of the LRRK2 Armadi...

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Identifiers and source

Literature Corpus work: ded59832-4dc0-5f32-b9cb-7d1a2054b025
DOI: 10.1101/2022.04.25.489459

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