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Article

Structure of LRRK1 and mechanisms of autoinhibition and activation.

Nature structural & molecular biology - 1 Nov 2023

Reimer Janice M, Dickey Andrea M, Lin Yu Xuan, Abrisch Robert G, Mathea Sebastian, Chatterjee Deep, Fay Elizabeth J, Knapp Stefan, Daugherty Matthew D, Reck-Peterson Samara L, Leschziner Andres E

Abstract excerpt

Leucine Rich Repeat Kinase 1 and 2 (LRRK1 and LRRK2) are homologs in the ROCO family of proteins in humans. Despite their shared domain architecture and involvement in intracellular trafficking, their disease associations are strikingly different: LRRK2 is involved in familial Parkinson's disease while LRRK1 is linked to bone diseases. Furthermore, Parkinson's disease-linked mutations in LRRK2 are typically...

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Identifiers

PMID: 37857821
DOI: 10.1038/s41594-023-01109-1
PMCID: PMC10643122

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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