Article

Structure of LRRK1 and mechanisms of autoinhibition and activation

2022-11-23

Abstract excerpt

Leucine Rich Repeat Kinase 1 and 2 (LRRK1 and LRRK2) are homologs in the ROCO family of proteins in humans. Despite their shared domain architecture and involvement in intracellular trafficking, their disease associations are strikingly different: LRRK2 is involved in familial Parkinson’s Disease (PD) while LRRK1 is linked to bone diseases. Furthermore, PD-linked mutations in LRRK2 are typically autosomal dominant...

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Literature Corpus work: 0f2c78e8-64dc-5f3b-825b-537a20eeb4cc
DOI: 10.1101/2022.11.22.517582

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