Article

The structural basis for LRRK2’s activation and autoinhibition

2026-06-03

Abstract excerpt

<h4>SUMMARY</h4> Mutations in Leucine-Rich Repeat Kinase 2 (LRRK2) are the second most common cause of autosomal-dominant Parkinson’s disease (PD), and increased LRRK2 kinase activity is also observed in idiopathic PD, making LRRK2 a major actionable therapeutic target. LRRK2 is a 286-kDa multidomain enzyme containing a Ras-like GTPase (ROC) and a kinase domain. Using cryo-EM, biochemical reconstitution, and cell...

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Literature Corpus work: c2e4f346-b2e1-56b9-9a70-155f6e606beb
DOI: 10.64898/2026.05.31.729085

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