Article

CK2 inhibition suppresses glial inflammation in the brain

2025-08-07

Abstract excerpt

<h4>ABSTRACT</h4> Neuroinflammation plays a key role in Alzheimer’s disease (AD) and related neurodegenerative disorders. Chronic activation of astrocytes and microglia fuels neuronal damage via cytokine secretion, oxidative stress, and proteolysis. However, glial inflammatory regulation remains poorly understood. Using chemoproteomics, we identified CK2, particularly the brain-enriched catalytic subunit CK2α2, a...

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Literature Corpus work: a02506f7-efd7-53a1-a4fe-f0608b3a6785
DOI: 10.1101/2025.08.05.668554

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