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Metabolic Reprogramming of Microglia Enhances Proinflammatory Cytokine Release through EphA2/p38 MAPK Pathway in Alzheimer’s Disease

7 Jun 2022

Abstract excerpt

BACKGROUND: The activation of microglia and neuroinflammation has been implicated in the pathogenesis of Alzheimer's disease (AD), but the exact roles of microglia and the underlying mechanisms remain unclear. OBJECTIVE: To clarify how the metabolic reprogramming of microglia induce by amyloid-β (Aβ)1-42 to affect the release of proinflammatory cytokines in AD. METHODS: MTS assay was used to detect the viability...

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PMID: 35694923
DOI: 10.3233/jad-220227

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