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Article

Adenylate kinase 5, a novel genetic risk factor for Alzheimer's disease, regulates microglial inflammatory activation.

Molecular brain - 26 Nov 2025

Seong Won Jae, An Sang Joon, Gim Jungsoo, Gupta Deepak Prasad, Park Junyoung, Kang Sarang, Lee Kun Ho, Song Gyun Jee

Abstract excerpt

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by memory loss, cognitive decline, and neuroinflammation, primarily mediated by microglia. In this study, we investigate the role of adenylate kinase 5 (AK5) in microglial function and its association with AD-related pathology. Analysis of brain tissues from AD patients and AD model mice revealed a significant reduction in AK5...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41299730
DOI: 10.1186/s13041-025-01257-z
PMCID: PMC12659495

Genes

AK5
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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