Article

Restoring hippocampal glucose metabolism rescues cognition across Alzheimer’s disease pathologies

2024-06-28

Abstract excerpt

<h4>ABSTRACT</h4> Impaired cerebral glucose metabolism is a pathologic feature of Alzheimer Disease (AD), and recent proteomic studies highlight a disruption of glial carbohydrate metabolism with disease progression. Here, we report that inhibition of indoleamine-2,3-dioxygenase 1 (IDO1), which metabolizes tryptophan to kynurenine (KYN) in the first step of the kynurenine pathway, rescues hippocampal memory funct...

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Literature Corpus work: 04a7ceaf-8b27-5c49-bafa-4881fc18db4e
DOI: 10.1101/2024.06.23.598940

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