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Article

Warburg-like metabolic transformation underlies neuronal degeneration in sporadic Alzheimer’s disease

19 Aug 2022

Abstract excerpt

The drivers of sporadic Alzheimer's disease (AD) remain incompletely understood. Utilizing directly converted induced neurons (iNs) from AD-patient-derived fibroblasts, we identified a metabolic switch to aerobic glycolysis in AD iNs. Pathological isoform switching of the glycolytic enzyme pyruvate kinase M (PKM) toward the cancer-associated PKM2 isoform conferred metabolic and transcriptional changes in AD iNs....

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PMID: 35987203
DOI: 10.1016/j.cmet.2022.07.014

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