Article

Epigenetic control of microglial mitochondrial immunity by KAT7 drives Alzheimer’s disease pathogenesis

2026-02-20

Abstract excerpt

<h4>ABSTRACT</h4> Mitochondrial DNA (mtDNA)-driven innate immune signaling sustains chronic neuroinflammation in neurological diseases such as Alzheimer’s disease (AD), yet how this pathway is regulated in microglia remains poorly understood. Here, we identify the histone acetyltransferase KAT7 (HBO1) as a central epigenetic regulator that links chromatin remodeling to mitochondrial immune activation. KAT7 and it...

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Literature Corpus work: 6d9a5a4e-80ed-5042-9bda-f8f0c760b4cc
DOI: 10.64898/2026.02.19.706884

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