Article

A locked immunometabolic switch underlies TREM2 R47H loss of function in human iPSC--derived microglia

2019-09-12

Abstract excerpt

Loss-of-function genetic variants of triggering receptor expressed on myeloid cells 2 (TREM2) are linked with an enhanced risk of developing dementias. Microglia, the resident immune cell of the brain, express TREM2 and microglial responses are implicated in dementia pathways. In a normal surveillance state, microglia use oxidative phosphorylation for their energy supply, but rely on the ability to undergo a meta...

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Literature Corpus work: 4d71d280-0990-510e-a957-641e9a9c99dc
DOI: 10.1101/766089

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