Article

Transcriptional and neuroprotective effects of hexokinase-2 inhibitors administered after stroke

2025-04-17

Abstract excerpt

<h4>ABSTRACT</h4> The inflammatory response induced by stroke can exacerbate injury to peri-infarct tissue. Microglia and other immune cells that mediate this response require increased glycolytic flux during pro-inflammatory activation. These cells, unlike neurons and most other cell types, utilize hexokinase-2 (HK2) rather than hexokinase-1 for glycolysis, such that HK2 inhibitors may selectively target them to...

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Literature Corpus work: a34bacba-dd41-5449-bdfc-e653b1be4de3
DOI: 10.1101/2025.04.11.648425

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