Article

Lactate treatment improves brain biochemistry and cognitive function in transgenic Alzheimer’s and wild-type mice

2026-01-31

Abstract excerpt

Lactate, a well-known metabolite and signalling molecule, holds therapeutic potential for neurodegenerative diseases. Here, we investigated the effects of chronic lactate treatment on cognition and molecular biomarkers in the 5XFAD mouse model of Alzheimer’s disease (AD) and in wild-type (WT) controls using behavioural testing alongside proteomic and transcriptomic analyses. Mice received lactate or vehicle inject...

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Literature Corpus work: ba29bad3-8b22-5cd5-8d94-84c222d3df50
DOI: 10.64898/2026.01.28.702254

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