Article

Patient iPSC-astrocytes show transcriptional and functional dysregulation in schizophrenia

2020-10-23

Abstract excerpt

Human astrocytes are multifunctional brain cells and may contribute to the pathophysiology of schizophrenia (SCZ). We differentiated astrocytes from induced pluripotent stem cells of monozygotic twins discordant for SCZ, and found sex-specific gene expression and signaling pathway alterations related particularly to inflammation and synaptic functions. While Ingenuity Pathway Analysis identified SCZ disease and sy...

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Literature Corpus work: f3227df9-441d-5888-9211-fe544170a83d
DOI: 10.1101/2020.10.23.350413

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