Article
Contribution of astrocytes to familial risk and clinical manifestation of schizophrenia.
Glia - 1 Apr 2022
Koskuvi Marja, Lehtonen Šárka, Trontti Kalevi, Keuters Meike, Wu Ying-Chieh, Koivisto Hennariikka, Ludwig Anastasia, Plotnikova Lidiia, Virtanen Pekka L J, Räsänen Noora, Kaipainen Satu, Hyötyläinen Ida, Dhungana Hiramani, Giniatullina Raisa, Ojansuu Ilkka, Vaurio Olli, Cannon Tyrone D, Lönnqvist Jouko, Therman Sebastian, Suvisaari Jaana, Kaprio Jaakko, Lähteenvuo Markku, Tohka Jussi, Giniatullin Rashid, Rivera Claudio, Hovatta Iiris, Tanila Heikki, Tiihonen Jari, Koistinaho Jari
Abstract excerpt
Previous studies have implicated several brain cell types in schizophrenia (SCZ), but the genetic impact of astrocytes is unknown. Considering their high complexity in humans, astrocytes are likely key determinants of neurodevelopmental diseases, such as SCZ. Human induced pluripotent stem cell (hiPSC)-derived astrocytes differentiated from five monozygotic twin pairs discordant for SCZ and five healthy subjects...
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