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Induced pluripotent stem cell-derived astrocytes from patients with schizophrenia exhibit an inflammatory phenotype that affects vascularization.

Molecular psychiatry - 1 Feb 2023

Trindade Pablo, Nascimento Juliana Minardi, Casas Bárbara S, Monteverde Tomás, Gasparotto Juciano, Ribeiro Camila Tiefensee, Devalle Sylvie, Sauma Daniela, Moreira José Claudio Fonseca, Gelain Daniel Pens, Porciuncula Lisiane O, Palma Verónica, Martins-de-Souza Daniel, Rehen Stevens K

Abstract excerpt

Molecular and functional abnormalities of astrocytes have been implicated in the etiology and pathogenesis of schizophrenia (SCZ). In this study, we examined the proteome, inflammatory responses, and secretome effects on vascularization of human induced pluripotent stem cell (hiPSC)-derived astrocytes from patients with SCZ. Proteomic analysis revealed alterations in proteins related to immune function and...

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PMID: 36280751
DOI: 10.1038/s41380-022-01830-1

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