Article
Specific glial functions contribute to schizophrenia susceptibility.
Schizophrenia bulletin - 1 Jul 2014
Goudriaan Andrea, de Leeuw Christiaan, Ripke Stephan, Hultman Christina M, Sklar Pamela, Sullivan Patrick F, Smit August B, Posthuma Danielle, Verheijen Mark H G
Abstract excerpt
Schizophrenia is a highly polygenic brain disorder. The main hypothesis for disease etiology in schizophrenia primarily focuses on the role of dysfunctional synaptic transmission. Previous studies have therefore directed their investigations toward the role of neuronal dysfunction. However, recent studies have shown that apart from neurons, glial cells also play a major role in synaptic transmission. Therefore,...
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