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Article

Human iPSC Glial Mouse Chimeras Reveal Glial Contributions to Schizophrenia.

Cell stem cell - 3 Aug 2017

Windrem Martha S, Osipovitch Mikhail, Liu Zhengshan, Bates Janna, Chandler-Militello Devin, Zou Lisa, Munir Jared, Schanz Steven, McCoy Katherine, Miller Robert H, Wang Su, Nedergaard Maiken, Findling Robert L, Tesar Paul J, Goldman Steven A

Abstract excerpt

In this study, we investigated whether intrinsic glial dysfunction contributes to the pathogenesis of schizophrenia (SCZ). Our approach was to establish humanized glial chimeric mice using glial progenitor cells (GPCs) produced from induced pluripotent stem cells derived from patients with childhood-onset SCZ. After neonatal implantation into myelin-deficient shiverer mice, SCZ GPCs showed premature migration...

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Identifiers

PMID: 28736215
DOI: 10.1016/j.stem.2017.06.012
PMCID: PMC5576346

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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