Article

A human iPSC-astroglia neurodevelopmental model reveals divergent transcriptomic patterns in schizophrenia

2020-11-07

Abstract excerpt

<h4>ABSTRACT</h4> While neurodevelopmental abnormalities have been associated with schizophrenia (SCZ), the role of astroglia in disease pathophysiology remains poorly understood. In this study we used a human induced pluripotent stem cell (iPSC)-derived astrocyte model to investigate the temporal patterns of astroglia differentiation during developmental stages critical for SCZ using RNA-sequencing. The model ge...

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Literature Corpus work: 22b523df-e8d1-5666-a9bb-05aa6bc4db89
DOI: 10.1101/2020.11.07.372839

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