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An efficient <i>in vivo</i> -inducible CRISPR interference system for group A <i>Streptococcus</i> genetic analysis and pathogenesis studies

2024-02-22

Abstract excerpt

While genome-wide transposon mutagenesis screens have identified numerous essential genes in the significant human pathogen Streptococcus pyogenes (group A Streptococcus or GAS), many of their functions remain elusive. This knowledge gap is attributed in part to the limited molecular toolbox for controlling GAS gene expression and the bacterium’s poor genetic transformability. CRISPR interference (CRISPRi), usin...

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Literature Corpus work
f2e6cf9e-8730-5214-9511-07767a2e78af
DOI
10.1101/2024.02.22.581527
Open publication

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An efficient <i>in vivo</i> -inducible CRISPR interference system for group A <i>Streptococcus</i> genetic analysis and pathogenesis studiesDOI 10.1101/2024.02.22.581527
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