Article

All-in-One Adeno-associated Virus Delivery and Genome Editing by <i>Neisseria meningitidis</i> Cas9 <i>in vivo</i>

2018-04-04

Abstract excerpt

Clustered, regularly interspaced, short palindromic repeats (CRISPR) and CRISPR-associated proteins (Cas) have recently opened a new avenue for gene therapy. Cas9 nuclease guided by a single-guide RNA (sgRNA) has been extensively used for genome editing. Currently, three Cas9 orthologs have been adapted for in vivo genome engineering applications: SpyCas9, SauCas9 and CjeCas9. However, additional in vivo editing...

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Literature Corpus work: 0cef0bb2-f7d8-55cf-befb-9939d5e059b8
DOI: 10.1101/295055

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