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Group B <i>Streptococcus</i> Cas9 variants provide insight into programmable gene repression and CRISPR-Cas transcriptional effects

2023-05-24

Abstract excerpt

Group B Streptococcus (GBS; S. agalactiae ) causes chorioamnionitis, neonatal sepsis, and can also cause disease in healthy or immunocompromised adults. GBS possesses a type II-A CRISPR-Cas9 system, which defends against foreign DNA within the bacterial cell. Several recent publications have shown that GBS Cas9 influences genome-wide transcription through a mechanism uncoupled from its function as a specific, RN...

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Identifiers and source

Literature Corpus work
c1ca48aa-ae36-52ef-be66-5edc13a988d8
DOI
10.1101/2023.05.24.542094
Open publication

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Group B <i>Streptococcus</i> Cas9 variants provide insight into programmable gene repression and CRISPR-Cas transcriptional effectsDOI 10.1101/2023.05.24.542094
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