An efficient in vivo -inducible CRISPR interference system for group A Streptococcus genetic analysis and pathogenesis studies

Abstract excerpt

ABSTRACT While genome-wide transposon mutagenesis screens have identified numerous essential genes in the significant human pathogen Streptococcus pyogenes (group A Streptococcus or GAS), many of their functions remain elusive. This knowledge gap is attributed in part to the limited molecular toolbox for controlling GAS gene expression and the bacterium’s poor genetic transformability. CRISPR interference...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Antimicrobial Resistance in Staphylococcus
• Share to Neonatal and Maternal Infections
• Share to Streptococcal Infections and Treatments