Article

A signaling inspired synthetic toolkit for efficient production of tyrosine phosphorylated proteins

2024-12-23

Abstract excerpt

Tyrosine phosphorylation is an important post-translational modification that regulates many biochemical signaling networks in multicellular organisms. To date, 46,000 tyrosines have been observed in human proteins, but relatively little is known about the function and regulation of most of these sites. A major challenge has been producing recombinant phosphoproteins in order to test the effects of phosphorylation...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f28fd64b-1a42-5a52-aa62-03f77cd818f3
DOI: 10.1101/2024.12.22.629992

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A signaling inspired synthetic toolkit for efficient production of tyrosine phosphorylated proteinsDOI 10.1101/2024.12.22.629992Read

An open library of human kinase domain constructs for automated bacterial expressionSemantic proximity Read

High-throughput profiling of sequence recognition by tyrosine kinases and SH2 domains using bacterial peptide displaySemantic proximity Read

Reprogramming protein kinase substrate specificity through synthetic mutationsSemantic proximity Read

Genetic Encoding of A Nonhydrolyzable Phosphotyrosine Analog in Mammalian CellsSemantic proximity Read

Profiling tyrosine kinase substrate recognition using bacterial peptide display and deep sequencingSemantic proximity Read

Engineering synthetic phosphorylation signaling networks in human cellsSemantic proximity Read

Unraveling kinase signaling pathways with chemical genetic and chemical proteomic approaches.Semantic proximity Read

Cell type-independent profiling of interactions between intracellular pathogens and the human phosphoproteomeSemantic proximity Read

Multiple Click-Selective tRNA Synthetases Expand Mammalian Cell-Specific Proteomics.Semantic proximity Read

A Chemical-genetics and Nanoparticle Enabled Approach for <i>in vivo</i> Protein Kinase AnalysisSemantic proximity Read

Structural characterization of autoinhibited c-Met kinase produced by coexpression in bacteria with phosphatase.Semantic proximity Read

Semisynthesis of unnatural amino acid mutants of paxillin: protein probes for cell migration studies.Semantic proximity Read