Article
Unraveling kinase signaling pathways with chemical genetic and chemical proteomic approaches.
Cell cycle (Georgetown, Tex.) - 1 Mar 2005
Beillard Emmanuel, Witte Owen N
Abstract excerpt
Protein kinases are involved in a wide variety of physiological and pathological processes. Small kinase inhibitor molecules are frequently used to dissect signaling pathways or to counteract oncogenic events. However, in many cases the precise role of a given inhibitor is not well understood. Besides a known primary target, potential secondary targets might be involved in the biological response to the drug. We...
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