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Article

Structural characterization of autoinhibited c-Met kinase produced by coexpression in bacteria with phosphatase.

Proceedings of the National Academy of Sciences of the United States of America - 7 Mar 2006

Wang Weiru, Marimuthu Adhirai, Tsai James, Kumar Abhinav, Krupka Heike I, Zhang Chao, Powell Ben, Suzuki Yoshihisa, Nguyen Hoa, Tabrizizad Maryam, Luu Catherine, West Brian L

Abstract excerpt

Protein kinases are a large family of cell signaling mediators undergoing intensive research to identify inhibitors or modulators useful for medicine. As one strategy, small-molecule compounds that bind the active site with high affinity can be used to inhibit the enzyme activity. X-ray crystallography is a powerful method to reveal the structures of the kinase active sites, and thus aid in the design of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Protein Tyrosine Phosphatase, Non-Receptor Type 1

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Identifiers

PMID: 16537444
DOI: 10.1073/pnas.0600048103
PMCID: PMC1450123

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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