Article

An open library of human kinase domain constructs for automated bacterial expression

2016-02-03

Abstract excerpt

Kinases play a critical role in many cellular signaling pathways and are dysregulated in a number of diseases, such as cancer, diabetes, and neurodegeneration. Since the FDA approval of imatinib in 2001, therapeutics targeting kinases now account for roughly 50% of current cancer drug discovery efforts. The ability to explore human kinase biochemistry, biophysics, and structural biology in the laboratory is essent...

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Literature Corpus work: 242368a1-26aa-55cf-931c-3986c587aba8
DOI: 10.1101/038711

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