Article

Genetic Encoding of A Nonhydrolyzable Phosphotyrosine Analog in Mammalian Cells

2021-12-01

Abstract excerpt

Protein tyrosine phosphorylation plays a critical role in signal transduction and the regulation of many cellular processes. It is of great significance to understand the underlying regulatory mechanism of particular tyrosine phosphorylation events. Here we report the genetic incorporation of a phosphotyrosine (pTyr) analog, p-carboxymethyl-L-phenylalanine (CMF), into proteins in mammalian cells. This nonhydrolyza...

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Literature Corpus work: b9449429-0f6a-5413-9979-d2e87f60b668
DOI: 10.1101/2021.11.30.470659

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