Article

Reprogramming protein kinase substrate specificity through synthetic mutations

2016-12-05

Abstract excerpt

Protein kinase specificity is largely imparted through substrate binding pocket motifs. Missense mutations in these regions are frequently associated with human disease, and in some cases can alter substrate specificity. However, current efforts at decoding the influence of mutations on substrate specificity have been focused on disease-associated mutations. Here, we adapted the Proteomic Peptide Library (ProPeL)...

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Identifiers and source

Literature Corpus work: 594d1368-41fe-5113-9e70-0665d0611759
DOI: 10.1101/091892

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