Article

High-throughput profiling of sequence recognition by tyrosine kinases and SH2 domains using bacterial peptide display

2022-08-01

Abstract excerpt

Tyrosine kinases and SH2 (phosphotyrosine recognition) domains have binding specificities that depend on the amino acid sequence surrounding the target (phospho)tyrosine residue. Although the preferred recognition motifs of many kinases and SH2 domains are known, we lack a quantitative description of sequence specificity that could guide predictions about signaling pathways or be used to design sequences for biome...

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Literature Corpus work: a8d6db64-8bb1-558e-a723-6fc4fca29954
DOI: 10.1101/2022.08.01.502334

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