Article

Engineering synthetic phosphorylation signaling networks in human cells

2023-09-11

Abstract excerpt

<h4>ABSTRACT</h4> Protein phosphorylation signaling networks play a central role in how cells sense and respond to their environment. Here, we describe the engineering of artificial phosphorylation networks in which “push-pull” motifs—reversible enzymatic phosphorylation cycles consisting of opposing kinase and phosphatase activities—are assembled from modular protein domain parts and then wired together to creat...

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Literature Corpus work: b35e7d3f-257e-51ea-ace6-be5c75da6bdd
DOI: 10.1101/2023.09.11.557100

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