Article

A Chemical-genetics and Nanoparticle Enabled Approach for <i>in vivo</i> Protein Kinase Analysis

2020-05-15

Abstract excerpt

The human kinome contains >500 protein kinases, and regulates up to 30% of the proteome. Kinase study is currently hindered by a lack of in vivo analysis approaches due to two factors: our inability to distinguish the kinase reaction of interest from those of other kinases in live cells and the cell impermeability of the ATP analogs. Herein, we tackled this issue by combining the widely used chemical genetic meth...

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Literature Corpus work: db5f41f8-2c88-51c1-825a-c31acea58172
DOI: 10.1101/2020.05.13.094573

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