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Extracellular ISG15 triggers ISGylation via a type-I interferon independent non-canonical mechanism to regulate host response during virus infection

2024-07-10

Abstract excerpt

Type-I interferons (IFN) induce cellular proteins with antiviral activity. One such protein is Interferon Stimulated Gene 15 (ISG15). ISG15 is conjugated to proteins during ISGylation to confer antiviral activity and regulate cellular activities associated with inflammatory and neurodegenerative diseases and cancer. Apart from ISGylation, unconjugated free ISG15 is also released from cells during various condition...

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Literature Corpus work
f2755805-5f6e-51e9-8461-72bbaa348e87
DOI
10.1101/2024.07.05.602290
Open publication

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Extracellular ISG15 triggers ISGylation via a type-I interferon independent non-canonical mechanism to regulate host response during virus infectionDOI 10.1101/2024.07.05.602290
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