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ISG-15, beyond its functions in the cell: a mini review

28 Jul 2025

Abstract excerpt

Interferon-stimulated gene 15 (ISG15) is an interferon-stimulated gene and a ubiquitin-like protein, traditionally known for its role in ISGylation. In addition to its intracellular functions, recent studies have revealed a novel role for extracellular ISG15, particularly in the context of viral infections. Beyond type I interferons, various stimuli, including viral and bacterial infections, have been found to...

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PMID: 40719862
DOI: 10.1007/s00018-025-05705-w

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