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Article

Consecutive Inhibition of ISG15 Expression and ISGylation by Cytomegalovirus Regulators

26 Aug 2016

Abstract excerpt

Interferon-stimulated gene 15 (ISG15) encodes an ubiquitin-like protein that covalently conjugates protein. Protein modification by ISG15 (ISGylation) is known to inhibit the replication of many viruses. However, studies on the viral targets and viral strategies to regulate ISGylation-mediated antiviral responses are limited. In this study, we show that human cytomegalovirus (HCMV) replication is inhibited by...

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PMID: 27564865
DOI: 10.1371/journal.ppat.1005850

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